Scientific Library
THE EVIDENCE,
IN THE OPEN.
This page documents selected literature informing the N° SYSTEM research approach — what the research shows, at which evidence level, and where it stops. Nothing here is a claim about the finished product.
The N° SYSTEM Evidence Standard
We show where the evidence is strong, where it is emerging — and where it stops.
Level 01 Mechanistic / Preclinical · Level 02 Human Ingredient · Level 03 Finished Formulation
Selected scientific literature
THE SOURCES BEHIND THE FRAMEWORK.
A curated starting point for the scientific principles that inform how we think about interconnected biology. These sources establish context; they do not validate the finished N°1 formulation.
- 01
Biology of ageing
Integrative scientific review
Hallmarks of Aging: An Expanding Universe
López-Otín C et al. (2023). Cell 186(2):243–278
- 02
Systems biology
Foundational scientific review
Systems Biology: A Brief Overview
Kitano H (2002). Science 295(5560):1662–1664
- 03
Mitochondrial biology
Mechanistic scientific review
Mitochondria: In Sickness and in Health
Nunnari J, Suomalainen A (2012). Cell 148(6):1145–1159
- 04
Redox regulation
Mechanistic scientific review
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies H, Jones DP (2020). Nature Reviews Molecular Cell Biology 21:363–383
- 05
Nutrient sensing
Mechanistic scientific review
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig S, Shaw RJ (2018). Nature Reviews Molecular Cell Biology 19:121–135
- 06
Cellular senescence
Consensus scientific review
Cellular Senescence: Defining a Path Forward
Gorgoulis V et al. (2019). Cell 179(4):813–827
This selection will expand as the research programme develops. References are linked to the publisher or DOI record wherever available.
Method
HOW WE READ A STUDY.
Source selection
Peer-reviewed primary literature, systematic reviews and official regulatory opinions. No press releases, no marketing material, no secondary blog summaries.
Context before headline
Every study is read with its dose, duration, population, endpoint and study design. A single positive endpoint does not become a claim.
Separation of levels
Mechanistic, human and product-level evidence are recorded separately and never merged into one statement.
Recorded limitations
Where evidence is weak, indirect or absent, that is stated on this page rather than omitted.
Formulation philosophy
HOW EVIDENCE BECOMES FORMULATION.
Evidence does not need to be overstated to be useful.
At N° SYSTEM, ingredient selection is not based on a single study, biomarker or mechanistic finding. We evaluate the totality of available evidence — including biological relevance, human data where available, mechanistic coherence, dose context, safety, bioavailability and compatibility within the complete formulation.
Where evidence is preliminary, preclinical or limited, we say so.
Scientific uncertainty is not something to hide. It is something to define.
What we do not claim
THE BOUNDARIES OF EVIDENCE.
- No clinical trial has been conducted on the finished N°1 formulation. Evidence-level 03 is currently empty by design.
- Ingredient-level research does not transfer automatically to a combination product, its dosages or its final matrix.
- No statement on this page is intended to diagnose, treat, cure or prevent any disease, or to slow, reverse or measure human ageing.
Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.