The science
AGEING IS
SYSTEMIC.
Ageing is not driven by one mechanism alone. The twelve Hallmarks of Aging describe interconnected processes — from changes in genetic information and cellular maintenance to tissue renewal, inflammation and microbial ecosystems. They influence one another across cells, tissues and the whole organism. Understanding ageing means understanding these relationships.
BETTER BIOLOGY. BETTER YOU.™
SCIENCE, WITHIN THE RULES.
We formulate with ingredients selected for compliance with the applicable EU food and supplement regulatory framework — without relying on unapproved novel ingredients.
Evidence-led. EU-compliant. No shortcuts.
Human need. Biological pathway.
ONE FORMULA. MULTIPLE BIOLOGICAL PATHWAYS. INTEGRATED IN ONE SYSTEM.
Cellular Reserve is formulated around a defined set of interconnected biological functions — its value lies in the rationale behind the combination.
Everyday energy
Cellular energy
Energy metabolism and mitochondrial function
Resilience under demand
Redox balance
Endogenous and direct redox support
Restoration and maintenance
Metabolic context
Intermediary metabolism and cellular cofactors
Healthy ageing over time
Cellular defence
Interconnected functions considered as one architecture
ICellular energy
NAD⁺ metabolism and ATP production.
IIRedox balance
Glutathione systems and oxidative regulation.
IIIMetabolic intermediates
Substrates at the centre of intermediary metabolism.
IVMicronutrient cofactors
Cofactors required by core enzymatic pathways.
VCellular resilience
The capacity of cells to absorb and recover from load.
Four filters shape the formulation: biology, human evidence, bioavailability and regulatory integrity.
Final consumer benefit wording will be validated against the completed formulation and applicable authorised EU health claims before launch.
The biology of ageing
TWELVE HALLMARKS. ONE NETWORK.
Across the human lifespan, biological ageing emerges from relationships between processes — not from one mechanism acting alone. The framework updated in 2023 describes twelve interconnected hallmarks.
N° SYSTEM
The 12 Hallmarks of Aging
One interconnected biology
Biological aging across the lifespan
Select a hallmark to focus
Select a process to trace its place within the network. No hallmark acts alone; each changes the context in which the others operate.
N° SYSTEM uses this systems perspective to organise evidence, biological relationships and formulation decisions.
This visualisation provides scientific context and does not represent a diagnostic model, individual trajectory or product outcome.
Framework to architecture
FROM SCIENTIFIC FRAMEWORK TO FORMULATION ARCHITECTURE.
The Hallmarks of Ageing describe the broader biology of ageing. The five N° SYSTEM domains serve a different purpose: they structure the nutritional and metabolic relationships considered during the development of N°1.
These domains intersect scientifically with selected Hallmarks, particularly in the context of mitochondrial function, nutrient sensing, proteostasis and cellular stress responses.
We map these intersections as part of formulation development, alongside evidence level, dose context and compatibility within the wider architecture.
Biological functional systems
HOW SYSTEMS BECOME A FORMULATION.
Biological functional systems are the organising logic behind N°1. They connect the scientific question to a deliberately bounded formulation architecture — without treating a biological relationship as evidence of a product outcome.
- 01
The system defines the question
N° SYSTEM begins with biological relationships rather than isolated ingredients. Connected functions are considered together to define a coherent formulation question.
- 02
N°1 defines the scope
For N°1, selected relationships are organised into five functional domains and translated into seven formulation layers. The domains explain why functions belong together; the layers give that logic a defined structure.
- 03
Evidence defines the interpretation
Evidence is then read at the level where it exists. Mechanistic findings inform biological rationale, human ingredient studies inform ingredient-level understanding, and only finished-formulation research can support conclusions about the complete product.
The five N°1 functional domains
- I
Cellular energy
NAD⁺ metabolism and ATP production.
- II
Redox balance
Glutathione systems and oxidative regulation.
- III
Metabolic intermediates
Substrates at the centre of intermediary metabolism.
- IV
Micronutrient cofactors
Cofactors required by core enzymatic pathways.
- V
Cellular resilience
The capacity of cells to absorb and recover from load.
THE FOUNDATIONS COME FIRST.
Sleep, physical activity, a balanced diet and appropriate medical care are essential foundations of healthy ageing.
N°1 is being developed as a complementary nutritional option. It does not replace these foundations or individually required medical advice or treatment.
The N° SYSTEM Evidence Standard
FROM MECHANISM TO EVIDENCE.
We show where the evidence is strong, where it is emerging — and where it stops.
We evaluate science across distinct levels — biological rationale, human evidence and finished-formulation evidence. Each answers a different question, and together they shape how N° SYSTEM formulations are developed.
- Level 01
Mechanistic context
What is biologically plausible?
Biochemical, cellular and preclinical findings can establish mechanistic plausibility. They do not automatically demonstrate an effect in humans.
- Level 02
Ingredient-level human evidence
What was observed, at what dose and in which population?
Human findings are assessed in relation to the specific ingredient form, dose, duration, population and endpoints investigated. Evidence relating to individual ingredients cannot automatically be extrapolated to a combined formulation.
- Level 03
Finished-formulation evidence
What can be shown for the complete final formulation?
Product-specific evidence requires the complete final formulation to be evaluated in appropriately designed human studies. The strength of that evidence depends on factors including study design, comparator, sample size, endpoints, duration and reproducibility.
Preclinical evidence is evidence. It is not human proof.
Mechanistic plausibility should not be presented as consumer certainty.
Mechanism is not proof.
A biological mechanism can explain why something might work. Human evidence tells us whether that promise survives outside the laboratory.
Ingredient evidence is not formulation evidence.
We will never borrow certainty from an ingredient study and pretend it proves the finished formulation.
The scientific literature provides context for the biological and nutritional relationships considered during the development of N°1.
N°1 is currently in development. Evidence is evaluated separately at the mechanistic, ingredient-human and finished-formulation levels.
Founder-developed. Disciplined in review.
“N° SYSTEM did not begin with a trending ingredient. It began with a question — which biological functions belong together — and with the discipline to claim only what the evidence supports.”
— Amal Bouzidi, Biologist · Longevity Science & Systems Biology · Founder and CEO, N° SYSTEM
References
- López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of Ageing: An Expanding Universe. Cell. 2023;186(2):243–278.
- Martinović A et al. Climbing the Longevity Pyramid: Overview of Evidence-Driven Healthcare Prevention Strategies for Human Longevity. Frontiers in Ageing. 2024.
The publications listed provide scientific context. Their inclusion does not imply that their authors, journals or institutions have reviewed, endorsed or recommended N° SYSTEM or N°1.
Scientific standards
THE N° SYSTEM STANDARD.
Evidence mapping
We map each ingredient by biological role, human evidence, dose context and the question it is intended to answer within the formulation.
Formulation compatibility
We assess stability, bioavailability, ingredient interactions and manufacturing requirements across the complete system.
Regulatory discipline
We apply regulatory discipline throughout development, from ingredient selection to precise scientific communication.
Quality validation
We define raw-material specifications, identity and contaminant testing, manufacturing controls and finished-product validation for final production.
SCIENCE IS THE FOUNDATION.
THE SYSTEM MAKES IT DAILY.
Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.